栄養化学研究室 > 研究業績

研究業績

原著論文・総説など

<2024年>

  • Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity, Y. Hirano, U. Ohto, I. Ichi, R. Sato, K. Miyake, T. Shimizu, Commun Biol, 7, 664, 2024 . DOI: 10.1038/s42003-024-06346-8, PMID: 38811802

<2023年>

  • Association of serum oxysterols with cholesterol metabolism markers and clinical factors in patients with coronary artery disease: A covariance structure analysis, Y. Akiyama, S. Katsuki, T. Matoba, Y. Nakano, S. Takase, S. Nakashiro, M. Yamamoto, Y. Mukai, S. Inoue, K. Oi, T. Higo, M. Takemoto, N. Suematsu, K. Eshima, K. Miyata, M. Usui, K. Sadamatsu, T. Kadokami, K. Hironaga, I. Ichi, K. Todaka, J. Kishimoto, H. Tsutsui, Nutrients, 15, 2997, 2023. DOI:10.3390/nu15132997
  • Impact of the COVID-19 pandemic on the glycemic control, eating habits, and body compositions of people with diabetes mellitus: A retrospective longitudinal observational study, M. Sawada, K. Ohkuma, M. Aihara, S. Doi, R. Sekine, T. Kaneko, S. Iimuro, I. Ichi, S. Usami, K. Ohe, T. Yamauchi, N. Kubota, Journal of Diabetes Investig, 14, 321-328, 2023. DOI:10.1111/jdi.13934
  • Excretion of triacylglycerol as a matrix lipid facilitating apoplastic accumulation of a lipophilic metabolite shikonin, K. Tatsumi, T. Ichino, N. Isaka, A. Sugiyama, E. Moriyoshi, Y. Okazaki, Y. Higashi, M. Kajikawa, Y. Tsuji, H. Fukuzawa, K. Toyooka, M. Sato, I. Ichi, K. Shimomura, H. Ohta , K. Saito, K. Yazaki, J Exp Bot, 74, 104-117, 2023. DOI:10.1093/jxb/erac405
  • Piceatannol prevents obesity and fat accumulation caused by estrogen deficiency in female mice by promoting lipolysis, K. Arisawa, M. Kaneko, A. Matsuoka, N. Ozawa, R. Kawawa, T. Ishikawa, I. Ichi, Y. Fujiwara, Nutrients, 15, 1374, 2023. DOI:10.3390/nu15061374
  • GPER/PKA-Dependent Enhancement of Hormone-Sensitive Lipase Phosphorylation in 3T3-L1 Adipocytes by Piceatannol, K. Arisawa, A Matsuoka, N. Ozawa, T. Ishikawa, I. Ichi, Y. Fujiwara, Nutrients, 16, 38, 2024. DOI:10.3390/nu16010038

<2022年>

  • FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication, D. Yamane, Y. Hayashi, M. Matsumoto, H. Nakanishi, H. Imagawa, M. Kohara, SM. Lemon, I. Ichi, Cell Chem Biol, 29, 799-810, 2022.
  • Dietary 7‑ketocholesterol exacerbates myocardial ischemia-eperfusion injury in mice through monocyte/macrophage‑mediated inflammation, T. Uchikawa, T. Matoba1, T. Kawahara, I. Baba, S. Katsuki, J. Koga, Y. Hashimoto, R. Yamasaki, I. Ichi, H. Akita, H. Tsutsu, Sci Rep, 12, 14902, 2022.
  • Effect of tocotrienol on the primary progression of nonalcoholic steatohepatitis in a mouse model, J. Noichi, T. Ishiakawa, I. Ichi, Y. Fujiwara, J Clin Biochem Nutr, 70, 140-146, 2022.
  • Effects of Vitamin E and Dietary Conditions on the Differentiation and Maturation of Osteoclast, Y. Fujiwara, Y. Ko, M. Sonoda, I. Ichi, T. Ishikawa, J Nutr Sci Vitaminol (Tokyo), 68, 73-77, 2022.
  •  A dietary oxysterol, 7-Ketocholesterol, exacerbates imiquimod-induced psoriasis-like dermatitis in steatohepatitic mice, A. Saga, M. Koseki, K. Kanno, J. Chang, T. Higo, D. Okuzaki, T. Okada, H. Inui, M. Asaji, K. Tanaka, T. Omatsu, S. Nishihara, Y. Zhu, K. Ito, H. Hattori, I. Ichi, Y. Kamada, M. Ono, T. Saibara, T. Ohama, S. Hikoso, M. Nishida, S. Yamashita, Y. Sakata, J Mol Sci, 23, 15855, 2022.

<2021年>

  • Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice, Y. Hayashi, HC. Lee-Okada, E. Nakamura, N. Tada, T. Yokomizo, Y. Fujiwara, I. Ichi*, FEBS letters, 595, 1920-1932, 2021. https://doi.org/10.1002/1873-3468.14134
  • The effect of polyunsaturated fatty acid deficiency on allergic response in ovalbumin-immunized mice, Y. Hayashi, Y. Yokomizo, Y. Fujiwara, I. Ichi*, Prostaglandins, Leukotrienes and Essential Fatty Acids, 164, 102231, 2021. doi: 10.1016/j.plefa.2020.102231.
  • Dietary oxysterol, 7-Ketocholesterol accelerates hepatic lipid accumulation and macrophage infiltration in obese Mice, J. Chang, M. Koseki, A. Saga, K. Kanno, T. Higo, D. Okuzaki, T. Okada, H. Inui, K. Tanaka, M. Asaji, Y. Zhu, K. Yamada, M. Ono, T. Saibara, I. Ichi, T. Ohama, M. Nishida, S. Yamashita, Y. Sakata, Front Endocrinol (Lausanne), 11, 614692, 2021.
  • FADS2 ablation exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice, Y. Hayashi, HC. Lee-Okada, E. Nakamura, N. Tada, T. Yokomizo, Y. Fujiwara, I. Ichi, FEBS letters, in press, 2021.
  • 多価不飽和脂肪酸欠乏によって生じる代替的な代謝機構〜欠乏の観点から脂質栄養重要性を明らかにする〜, 市 育代, 化学と生物,  Vol59, No.7, 333-338, 2021.

<2020年以前>

  • FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion, Y. Hayashi, A. Shimamura, T. Ishikawa, Y. Fujiwara, I. Ichi*, Biochem Biophys Res Commun, 496, 549-555, 2018. doi: 10.1016/j.bbrc.2018.01.064.
  • Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion: A Role of Serum Oxysterols, K. Honda, T. Matoba, Y. Antoku, J.I. Koga, I. Ichi, K. Nakano, H. Tsutsui, K. Egashira, Arterioscler Thromb Vasc Biol, 38, 757-771, 2018. doi:10.1161/ATVBAHA.117.310244
  • Fatty acid composition profiles of 235 strains of 3 plantae phylum within the NIES algal collection, E. Mitani, F. Nakayama, I. Matsuwaki, I. Ichi, A. Kawabata, M. Kawachi, M. Kato, Microb Resour Syst, 33, 19-29, 2017.
  • Excessive vitamin E intake does not cause bone loss in male or ovariectomized female mice fed normal or high-fat diets, H. Ikegami, R. Kawawa, I. Ichi, T. Ishikawa, T. Koike, Y. Aoki, Y. Fujiwara, J Nutr, 147, 1932-1937, 2017. doi: 10.3945/jn.117.248575.
  • Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4, Fujiwara, C. Tsukahara, N. Ikeda, Y. Sone, T. Ishikawa, I. Ichi, T. Koike, Y. Aoki, J Clin Biochem Nutr, 61, 196-202, 2017.
  • Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial, Takase, T. Matoba, S. Nakashiro, Y. Mukai, S. Inoue, K. Oi, T. Higo, S. Katsuki, M. Takemoto, N. Suematsu, K. Eshima, K. Miyata, M. Yamamoto, M. Usui, K. Sadamatsu, S. Satoh, T. Kadokami, K .Hironaga, I. Ichi, K. Todaka, J. Kishimoto, K. Egashira, K. Sunagawa, Arterioscler Thromb Vasc Biol, 37, 350-358, 2017. DOI: 10.1161/ATVBAHA. 116.308388
  • Saturated fatty acid in the phospholipid monolayer contributes to the formation of large lipid droplets, K. Arisawa, H. Mitsudome, K. Yoshida, S. Sugimoto, T. Ishikawa, Y. Fujiwara, I. Ichi*, Biochem Biophys Res Commun, 480, 641-7, 2016.  DOI: 10.1016/j.bbrc.2016.10.109, * Corresponding author
  • TTC39B Deficiency Stabilizes LXR Leading to Decreased Atherosclerosis and Hepatic Steatosis, Koseki, J. Hsieh, M. M. Molusky, E. Yakushiji, I. Ichi, M. Westerterp, S. Abramowicz, L. Tascau, C. B. Welch, J. Iqbal, S. Takiguchi, S. Yamashita, M. M. Hussain, D. J. Rader, A. R. Tall, Nature, 535, 303-7, 2016. DOI: 10.1038/nature18628
  • Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency, I.  Ichi, N. Kono, Y. Arita, S. Haga, K. Arisawa, M. Yamano, M. Nagase, Y. Fujiwara, H. Arai, Biochim Biophys Acta-Molecular and Cell Biology of Lipids, 1841, 204-13, 2014. DOI: 10.1016/j.bbalip. 2013.10.013
  • Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family, O. Udagawa, C. Ito, N. Ogonuki,; H. Sato, S. Lee, T. Pearlta, I. Ichi, Y. Uchida, T. Nishimura, M. Murakami, A. Ogura, T. Inoue, K. Toshimori, H. Arai, Gene to cells, 19, 13-27, 2014. DOI: 10.1111/gtc. 12105
  • Effecacy of habitual exercise for improving lipid profiles depends on the PPARg genotype in Japanese males, Y. Sone, R. Hirasawa, I. Ichi, T. Ishikawa, S. Kodama, H. Sone, S. Egawa, K. Kawahara, Y, Otsuka, Y. Fujiwara, J Nutr Sci Vitaminol  (Tokyo), 60, 66-70, 2014.
  • Changes in the phospholipid fatty acid composition of the lipid droplet during the differentiation of 3T3-L1 adipocytes, K. Arisawa, I. Ichi *, Y. Yasukawa, Y. Sone, Y. Fujiwara, J Biochem, 154, 281-289, 2013. DOI:10.1093/jb/mvt051, * Corresponding author
  • Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation, Y. Takahashi, A. Shinoda, N. Furuya, E. Harada, N. Arimura, I.  Ichi, Y. Fujiwara, J. Inoue, R. Sato, PLoS One, 29, e64605, 2013. DOI: 10.1371/journal.pone.0064605.
  • Genetic variants of the fatty acid desaturase gene cluster are associated with plasma LDL cholesterol levels in Japanese males, Y. Sone Y, T. Kido, T. Ainuki, M. Sonoda, I. Ichi, S. Kodama, H. Sone, K. Kondo, Y. Morita, S. Egawa, K. Kawahara, Y. Otsuka, Y. Fujiwara, J Nutr Sci Vitaminol (Tokyo), 59, 325-335, 2013.
  • Racemization of the aspartic acid residue of amyloid-β peptide by a radical reaction, K. Tambo, T. Yamaguchi, K. Kobayashi, E. Terauchi, Ichi, S. Kojo, Biosci Biotechnol Biochem, 77, 416-418, 2013.
  • Regulation of peroxisomal lipid metabolism by the catalytic activity of the tumor suppressor H-rev107, T. Uyama, I. Ichi, N. Kono, A. Inoue, K. Tsuboi, XH. Jin, N. Araki, J. Aoki, H. Arai, N. Ueda, J Biol Chem, 287, 2706-2718, 2012. DOI: 10.1074/jbc.M111.267575
  • The role of Kupffer cells in carbon tetrachloride intoxication in mice, K. Kiso, S. Ueno, M. Fukuda, I.  Ichi, K. Kobayashi, T. Sakai, K. Fukui, S. Kojo, Biol Pharm Bull, 35, 980-983, 2012. (IF; 1.849)
  • Increase in plasma ceramide levels via secretory sphingomyelinase activity in streptozotocin-induced diabetic rats, Kobayashi, I. Ichi*, T. Nakagawa, C. Kamikawa, Y. Kitamura, E. Koga, Y. Washino, Y. Hoshinaga, S. Kojo*, Med Chem Comm, 2, 536-541, 2011.  * Corresponding author
  • Oxidative stress in the ischemic and non-ischemic parts of the rat liver after two-thirds ischemia/reperfusion, Y. Kitamura, Y. Washino, E. Koga, A. Ito, M. Kawagoe, C. Nakazaki, K. Kiso, I. Ichi, T. Matsura, S. Kojo, Biosci Biotechnol Biochem, 74, 979-983, 2010.
  • Effect of nobiletin on lipid metabolism in rats, E. Nagata,  I. Ichi, R. Kataoka, M. Matsushima, N. Adachi, Y. Kitamura, T. Sasaki, S. Kojo, J Health Sci, 56, 705-711, 2010.
  • S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species, N. Takuwa, S. Ohkura, S. Takashima, F. Wang, T. Tanaka, K. Hirano, Y. Banno, M. Sasaki, Ichi, Y. Okamoto, K. Yoshioka, W. Du, M. Okamura, N. Sugimoto, K. Mizugishi, Y. Nakamura, I. Ishii, M. Takamura, S. Kaneko, S. Kojo, K. Satouchi, K. Mitumori, J. Chun, Y. Takuwa, Cardiovasc Res, 85, 484-493, 2010. DOI: 10.1093/cvr/cvp312
  • Effect of celecoxib, a selective cyclooxygenase-2 inhibitor on carbon tetrachloride intoxication in rats, Y. Washino, E. Koga, Y. Kitamura, C. Kamikawa, K. Kobayashi, T. Nakagawa, C. Nakazaki, I. Ichi, S. Kojo, Biol Pharm Bull, 33, 707-709, 2010.
  • Oxidative stress in the ischemic and non-ischemic parts of the rat liver after two-thirds ischemia/reperfusion, Kitamura, Y. Washino, E. Koga, A. Ito, M. Kawagoe, C. Nakazaki, K. Kiso, I. Ichi, T. Matsura, S. Kojo, Biosci Biotechnol Biochem, 74, 979-983, 2010.
  • Neutral sphingomyelinase-induced ceramide accumulation by oxidative stress during carbon tetrachloride intoxication, I. Ichi, C. Kamikawa, T. Nakagawa, K. Kobayashi, R. Kataoka, E. Nagata, Y. Kitamura, C. Nakazaki, T. Matsura, S. Kojo, Toxicology, 261, 33-40, 2009. DOI: 10.1016/j.tox.2009.04.040
  • The beneficial effect of propolis on fat accumulation and lipid metabolism in rats fed a high-fat diet, I. Ichi, H. Hori, Y. Takashima, N. Adachi, R. Kataoka, K. Okihara, K. Hashimoto, S. Kojo, J Food Sci, 74, H127-H131, 2009.
  • Effect of a-tocopherol on carbon tetrachloride intoxication in the rat liver. Iida, K. Fujii, E. Koga, Y. Washino, Y. Kitamura, I. Ichi, K. Abe, T. Matsura, S. Kojo, Arch Toxicol, 83, 477-483, 2009. DOI: 10.1007/s00204-008-0394-7
  • The effect of dietary cholesterol and high fat on ceramide concentration in rat tissues, I. Ichi, K. Nakahara, K. Kiso, S. Kojo, Nutrition, 23, 570-574, 2007.
  • Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein B-100 in apoE deficient mice, I. Ichi, Y. Takashima, N. Adachi, K. Nakahara, C. Kamikawa, M. Harada-Shiba, S. Kojo, Lipids, 42, 893-900, 2007.
  • Effect of dimethyl sulphoxide on oxidative stress, activation of mitogen activated protein kinase and necrosis caused by thioacetamide in the rat liver, T. Kishioka, C. Iida, K. Kozue, R. Nagae, Y. Onishi, I. Ichi, S. Kojo, Eur J Pharmacol, 564, 190-195, 2007.
  • Increase of ceramide in the liver and plasma after carbon tetrachloride intoxication in the rat, I. Ichi, K. Nakahara, K. Fujii, C. Iida, Y. Miyashita, S. Kojo, J Nutr Sci Vitaminol, 53, 53-56, 2007.
  • Inhibitory effect of dimethyl sulfoxide (DMSO) on necrosis and oxidative stress caused by D-galactosamine in the rat liver, C. Iida, K. Fujii, E. Koga, Y. Washino, I. Ichi, S. Kojo, J Nutr Sci Vitaminol, 53, 160-165, 2007.
  • Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat live, C. Iida, K. Fujii, T. Kishioka, R. Nagae, Y. Onishi, I. Ichi, S. Kojo, Toxicol, 81, 489-493, 2007.
  • Association of ceramides in human plasma with risk factors of atherosclerosis, I. Ichi, K. Nakahara, Y. Miyashita, A. Hidaka, S. Kutsukake, K. Inoue, T. Maruyama, Y. Miwa, M. Harada-Shiba, M. Tsushima, S. Kojo, Kisei Cohort Study Group, Lipids, 41, 859-863, 2006.
  • Activation of mitogen activated protein kinase (MAPK) during D-galactosamine intoxication in the rat liver, H. Nishioka, T. Kishioka, C. Iida, K. Fujii, I. Ichi, S. Kojo, Bioorg Med Chem Lett, 16, 3019-3022, 2006.
  • 日本人におけるコレステロール酸化物と植物ステロール酸化物の摂取量, 市 育代, 岩本昌子, 友寄博子, 佐藤匡央, 池田郁男, 今泉勝己, 日本栄養・食糧学会誌, 58, 145-150, 2005.
  • Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but not accelerate atherosclerosis in apolipoprotein E-deficient mice, Tomoyori, Y. Kawata, T. Higuchi, I. Ichi, H. Sato, M. Sato, I. Ikeda, K. Imaizumi, J Nutr,  134, 1690-1696, 2004.
  • 肥満児と非肥満児における脂肪酸, コレステロールおよび植物ステロールの1日の摂取量. 石永正隆, 望月てる代, 上田愛子, 市 育代, 七枝美香, 小田光子, 岸田典子,日本栄養・食糧学会誌, 54, 291-295, 2001.

著書　その他

  1. 脂質・脂肪酸関連物質の使いこなし方, 有澤琴子, 市 育代, p69-74, 株式会社テクノシステム, 分担執筆, 2020.
  2. 食品と生体内に存在するオキシステロール, 市 育代, Heart View, 第22巻, 第7号, p60-64, 2018.
  3. 脂肪滴の大きさを調節する脂肪滴膜タンパク質と膜脂質 -脂肪滴の”表面”が脂肪滴のサイズを決める, 有澤琴子, 市　育代, 化学と生物, Vol. 56, No. 4, 2018.
  4. 新スタンダード栄養・食物シリーズ13臨床栄養学, 東京化学同人, 分担執筆, 2017.
  5. 栄養科学シリーズNEXT 臨床栄養学実習第2版, 講談社, 分担執筆, 2017.
  6. 新スタンダード栄養・食物シリーズ9 基礎栄養学, 東京化学同人, 分担執筆, 2015.
  7. 栄養, 実教出版株式会社,分担執筆, 2015.
  8. 栄養科学イラストレイテッド 分子栄養学 遺伝子の基礎からわかる, 羊土社, 2014.
  9. スマート栄養管理-栄養とスポーツの管理が重要であるこれだけの理由, 医歯薬出版, 分担執筆, 2014.
  10. 基礎生化学-健康・疾病とのつながり, アイ・ケイコーポレーション, 分担執筆, 2013.
  11. ビタミンの新栄養学, 講談社, 分担執筆, 2012.
  12. 食物と栄養学基礎シリーズ7　基礎栄養学, 学文社, 分担執筆, 2012.
  13. Antioxidants as biomarkers of oxidative stress. I. Ichi, S. Kojo, In biomarkers for antioxidant defense and oxidative damage: Principles and practical applications (Ed., G. Aldini, K.-J. Yeum, E. Niki, R. M. Russell) pp. 35-49, Wiley-Blackwell, Iowa, USA, 2010.
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