市 育代 (研究業績)

原著論文

<2021年>
    • FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication, D. Yamane, Y. Hayashi, M. Matsumoto, H. Nakanishi, H. Imagawa, M. Kohara, SM. Lemon, I. Ichi, Cell Chem Biol., 29, 1-12, (2022)
    • Ablation of fatty acid desaturase 2 (FADS2) exacerbates hepatic triacylglycerol and cholesterol accumulation in polyunsaturated fatty acid-depleted mice, Y. Hayashi, HC. Lee-Okada, E. Nakamura, N. Tada, T. Yokomizo, Y. Fujiwara, I. Ichi*, FEBS letters, 595, 1920-1932, 2021. https://doi.org/10.1002/1873-3468.14134
    • The effect of polyunsaturated fatty acid deficiency on allergic response in ovalbumin-immunized mice, Y. Hayashi, Y. Yokomizo, Y. Fujiwara, I. Ichi*, Prostaglandins, Leukotrienes and Essential Fatty Acids, 164, 102231, 2021. doi: 10.1016/j.plefa.2020.102231.
    • Dietary oxysterol, 7-Ketocholesterol accelerates hepatic lipid accumulation and macrophage infiltration in obese Mice, J. Chang, M. Koseki, A. Saga, K. Kanno, T. Higo, D. Okuzaki, T. Okada, H. Inui, K. Tanaka, M. Asaji, Y. Zhu, K. Yamada, M. Ono, T. Saibara, I Ichi, T. Ohama, M. Nishida, S. Yamashita, Y. Sakata, Front Endocrinol (Lausanne),  11, 614692, 2021. doi: 10.3389/fendo.2020.614692
    • 多価不飽和脂肪酸欠乏によって生じる代替的な代謝機構〜欠乏の観点から脂質栄養重要性を明らかにする〜, 市 育代, 化学と生物,  Vol59, No.7, 333-338, 2021
  • <2020年以前>
    • FADS2 inhibition in essential fatty acid deficiency induces hepatic lipid accumulation via impairment of very low-density lipoprotein (VLDL) secretion, Y. Hayashi, A. Shimamura, T. Ishikawa, Y. Fujiwara, I. Ichi*, Biochem. Biophys. Res. Commun., (2018), 496, 549-555. doi: 10.1016/j.bbrc.2018.01.064.
    • Lipid-Lowering Therapy With Ezetimibe Decreases Spontaneous Atherothrombotic Occlusions in a Rabbit Model of Plaque Erosion: A Role of Serum Oxysterols, K. Honda, T. Matoba, Y. Antoku, J.I. Koga, I. Ichi, K. Nakano, H. Tsutsui, K. Egashira, Arterioscler Thromb Vasc Biol. (2018), 38, 757-771. doi:10.1161/ATVBAHA.117.310244
    • Fatty acid composition profiles of 235 strains of 3 plantae phylum within the NIES algal collection, E. Mitani, F. Nakayama, I. Matsuwaki, I. Ichi, A. Kawabata, M. Kawachi, M. Kato, Microb. Resour. Syst., (2017), 33, 19-29.
    • Excessive vitamin E intake does not cause bone loss in male or ovariectomized female mice fed normal or high-fat diets, H. Ikegami, R. Kawawa, I. Ichi, T. Ishikawa, T. Koike, Y. Aoki, Y.Fujiwara, J. Nutr., (2017), 147, 1932-1937. doi: 10.3945/jn.117.248575.
    • Oleuropein improves insulin resistance in skeletal muscle by promoting the translocation of GLUT4, Fujiwara, C. Tsukahara, N. Ikeda, Y. Sone, T. Ishikawa, I. Ichi, T. Koike, and Y. Aoki, J. Clin. Biochem. Nutr., (2017), 61, 196-202.
    • Ezetimibe in Combination With Statins Ameliorates Endothelial Dysfunction in Coronary Arteries After Stenting: The CuVIC Trial (Effect of Cholesterol Absorption Inhibitor Usage on Target Vessel Dysfunction After Coronary Stenting), a Multicenter Randomized Controlled Trial, Takase, T. Matoba, S. Nakashiro, Y. Mukai, S. Inoue, K. Oi, T. Higo, S. Katsuki, M. Takemoto, N. Suematsu, K. Eshima, K. Miyata, M. Yamamoto, M. Usui, K. Sadamatsu, S. Satoh, T. Kadokami, K .Hironaga, I. Ichi, K. Todaka, J. Kishimoto, K. Egashira, K. Sunagawa, Arterioscler Thromb Vasc Biol., 37, 350-358 (2017), DOI: 10.1161/ATVBAHA. 116.308388
    • Saturated fatty acid in the phospholipid monolayer contributes to the formation of large lipid droplets, K. Arisawa, H. Mitsudome, K. Yoshida, S. Sugimoto, T. Ishikawa, Y. Fujiwara, I. Ichi*, Biochem. Biophys. Res. Commun., 480, 641-7 (2016) , DOI: 10.1016/j.bbrc.2016.10.109, * Corresponding author
    • TTC39B Deficiency Stabilizes LXR Leading to Decreased Atherosclerosis and Hepatic Steatosis, Koseki, J. Hsieh, M. M. Molusky, E. Yakushiji, I. Ichi, M. Westerterp, S. Abramowicz, L. Tascau, C. B. Welch, J. Iqbal, S. Takiguchi, S. Yamashita, M. M. Hussain, D. J. Rader, and A. R. Tall, 535, 303-7, Nature, (2016), DOI: 10.1038/nature18628
    • Identification of genes and pathways involved in the synthesis of Mead acid (20:3n-9), an indicator of essential fatty acid deficiency, I.  Ichi, N. Kono, Y. Arita, S. Haga, K. Arisawa, M. Yamano, M. Nagase, Y. Fujiwara, H. Arai, Biochim. Biophys. Acta.-Molecular and Cell Biology of Lipids, 1841, 204-13 (2014), DOI: 10.1016/j.bbalip. 2013.10.013
    • Oligo-astheno-teratozoospermia in mice lacking ORP4, a sterol-binding protein in the OSBP-related protein family, O. Udagawa, C. Ito, N. Ogonuki,; H. Sato, S. Lee, T. Pearlta, I.  Ichi, Y. Uchida, T. Nishimura, M. Murakami, A. Ogura, T. Inoue, K. Toshimori, H. Arai, Gene to cells, 19, 13-27 (2014), DOI: 10.1111/gtc. 12105
    • Effecacy of habitual exercise for improving lipid profiles depends on the PPARg genotype in Japanese males, Y. Sone, R. Hirasawa, I. Ichi, T. Ishikawa, S. Kodama, H. Sone, S. Egawa, K. Kawahara, Y, Otsuka, Y. Fujiwara, J. Nutr. Sci. Vitaminol. (Tokyo), 60, 66-70 (2014)
    • Changes in the phospholipid fatty acid composition of the lipid droplet during the differentiation of 3T3-L1 adipocytes, K. Arisawa, I. Ichi *, Y. Yasukawa, Y. Sone, Y. Fujiwara, J. Biochem., 154, 281-289 (2013) DOI:10.1093/jb/mvt051, * Corresponding author
    • Perilipin-mediated lipid droplet formation in adipocytes promotes sterol regulatory element-binding protein-1 processing and triacylglyceride accumulation, Y. Takahashi, A. Shinoda, N. Furuya, E. Harada, N. Arimura, I.  Ichi, Y. Fujiwara, J. Inoue, R. Sato, PLoS One, 29, e64605 (2013) DOI: 10.1371/journal.pone.0064605.
    • Genetic variants of the fatty acid desaturase gene cluster are associated with plasma LDL cholesterol levels in Japanese males, Y. Sone Y, T. Kido, T. Ainuki, M. Sonoda, I. Ichi, S. Kodama, H. Sone, K. Kondo, Y. Morita, S. Egawa, K. Kawahara, Y. Otsuka, Y. Fujiwara, J. Nutr. Sci. Vitaminol. (Tokyo), 59, 325-335 (2013)
    • Racemization of the aspartic acid residue of amyloid-β peptide by a radical reaction, K. Tambo, T. Yamaguchi, K. Kobayashi, E. Terauchi, Ichi, S. Kojo, Biosci Biotechnol Biochem. 77, 416-418 (2013)
    • Regulation of peroxisomal lipid metabolism by the catalytic activity of the tumor suppressor H-rev107, T. Uyama, I. Ichi, N. Kono, A. Inoue, K. Tsuboi, XH. Jin, N. Araki, J. Aoki, H. Arai, N. Ueda, J. Biol. Chem. 287, 2706-2718 (2012), DOI: 10.1074/jbc.M111.267575
    • The role of Kupffer cells in carbon tetrachloride intoxication in mice, K. Kiso, S. Ueno, M. Fukuda, I.  Ichi, K. Kobayashi, T. Sakai, K. Fukui, and S. Kojo, Biol. Pharm. Bull, 35, 980-983 (2012) (IF; 1.849)
    • Increase in plasma ceramide levels via secretory sphingomyelinase activity in streptozotocin-induced diabetic rats, Kobayashi, I. Ichi*, T. Nakagawa, C. Kamikawa, Y. Kitamura, E. Koga, Y. Washino, Y. Hoshinaga, S. Kojo*, Med. Chem. Comm., 2, 536-541, (2011), * Corresponding author
    • Oxidative stress in the ischemic and non-ischemic parts of the rat liver after two-thirds ischemia/reperfusion, Y. Kitamura, Y. Washino, E. Koga, A. Ito, M. Kawagoe, C. Nakazaki, K. Kiso, I. Ichi, T. Matsura, S. Kojo, Biosci Biotechnol Biochem., 74, 979-983, (2010)
    • Effect of nobiletin on lipid metabolism in rats, E. Nagata,  I. Ichi, R. Kataoka, M. Matsushima, N. Adachi, Y. Kitamura, T. Sasaki, and S. Kojo, J. Health Sci., 56, 705-711 (2010)
    • S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species, N. Takuwa, S. Ohkura, S. Takashima, F. Wang, T. Tanaka, K. Hirano, Y. Banno, M. Sasaki, Ichi, Y. Okamoto, K. Yoshioka, W. Du, M. Okamura, N. Sugimoto, K. Mizugishi, Y. Nakamura, I. Ishii, M. Takamura, S. Kaneko, S. Kojo, K. Satouchi, K. Mitumori, J. Chun, and Y. Takuwa, Cardiovasc. Res., 85, 484-493 (2010), DOI: 10.1093/cvr/cvp312
    • Effect of celecoxib, a selective cyclooxygenase-2 inhibitor on carbon tetrachloride intoxication in rats, Y. Washino, E. Koga, Y. Kitamura, C. Kamikawa, K. Kobayashi, T. Nakagawa, C. Nakazaki, I. Ichi, and S. Kojo, Biol. Pharm. Bull., 33, 707-709 (2010)
    • Oxidative stress in the ischemic and non-ischemic parts of the rat liver after two-thirds ischemia/reperfusion, Kitamura, Y. Washino, E. Koga, A. Ito, M. Kawagoe, C. Nakazaki, K. Kiso, I. Ichi, T. Matsura, and S. Kojo, Biosci. Biotechnol. Biochem., 74, 979-983 (2010)
    • Neutral sphingomyelinase-induced ceramide accumulation by oxidative stress during carbon tetrachloride intoxication, I. Ichi, C. Kamikawa, T. Nakagawa, K. Kobayashi, R. Kataoka, E. Nagata, Y. Kitamura, C. Nakazaki, T. Matsura, and S. Kojo, Toxicology, 261, 33-40 (2009) DOI: 10.1016/j.tox.2009.04.040
    • The beneficial effect of propolis on fat accumulation and lipid metabolism in rats fed a high-fat diet, I. Ichi, H. Hori, Y. Takashima, N. Adachi, R. Kataoka, K. Okihara, K. Hashimoto, and S. Kojo, J. Food. Sci., 74, H127-H131 (2009)
    • Effect of a-tocopherol on carbon tetrachloride intoxication in the rat liver. Iida, K. Fujii, E. Koga, Y. Washino, Y. Kitamura, I. Ichi, K. Abe, T. Matsura, and S. Kojo, Arch. Toxicol., 83, 477-483 (2009) DOI: 10.1007/s00204-008-0394-7
    • The effect of dietary cholesterol and high fat on ceramide concentration in rat tissues, I.  Ichi, K. Nakahara, K. Kiso, and S. Kojo, Nutrition, 23, 570-574 (2007)
    • Effects of dietary cholesterol on tissue ceramides and oxidation products of apolipoprotein B-100 in apoE deficient mice, I. Ichi, Y. Takashima, N. Adachi, K. Nakahara, C. Kamikawa, M. Harada-Shiba, and S. Kojo, Lipids, 42, 893-900 (2007)
    • Effect of dimethyl sulphoxide on oxidative stress, activation of mitogen activated protein kinase and necrosis caused by thioacetamide in the rat liver, T. Kishioka, C. Iida, K. Kozue, R. Nagae, Y. Onishi, I. Ichi, and S. Kojo, Eur. J. Pharmacol., 564, 190-195 (2007)
    • Increase of ceramide in the liver and plasma after carbon tetrachloride intoxication in the rat, I. chi, K. Nakahara, K. Fujii, C. Iida, Y. Miyashita, and S. Kojo, J. Nutr. Sci. Vitaminol. 53, 53-56 (2007)
    • Inhibitory effect of dimethyl sulfoxide (DMSO) on necrosis and oxidative stress caused by D-galactosamine in the rat liver, C. Iida, K. Fujii, E. Koga, Y. Washino, I. Ichi, and S. Kojo, J. Nutr. Sci. Vitaminol., 53, 160-165 (2007)
    • Activation of mitogen activated protein kinase (MAPK) during carbon tetrachloride intoxication in the rat live, C. Iida, K. Fujii, T. Kishioka, R. Nagae, Y. Onishi, I. Ichi, S. Kojo, Toxicol., 81, 489-493 (2007)
    • Association of ceramides in human plasma with risk factors of atherosclerosis, I. Ichi, K. Nakahara, Y. Miyashita, A. Hidaka, S. Kutsukake, K. Inoue, T. Maruyama, Y. Miwa, M. Harada-Shiba, M. Tsushima, S. Kojo, and Kisei Cohort Study Group, Lipids, 41, 859-863 (2006)
    • Activation of mitogen activated protein kinase (MAPK) during D-galactosamine intoxication in the rat liver, H. Nishioka, T. Kishioka, C. Iida, K. Fujii, I.  Ichi, and S. Kojo, Bioorg. Med. Chem. Lett., 16, 3019-3022 (2006)
    • 日本人におけるコレステロール酸化物と植物ステロール酸化物の摂取量, 育代, 岩本昌子, 友寄博子, 佐藤匡央, 池田郁男, 今泉勝己, 日本栄養・食糧学会誌, 58, 145-150 (2005).
    • Phytosterol oxidation products are absorbed in the intestinal lymphatics in rats but not accelerate atherosclerosis in apolipoprotein E-deficient mice, Tomoyori, Y. Kawata, T. Higuchi, I. Ichi, H. Sato, M. Sato, I. Ikeda, K. Imaizumi, J. Nutr. 134, 1690-1696 (2004)
    • 肥満児と非肥満児における脂肪酸, コレステロールおよび植物ステロールの1日の摂取量. 石永正隆, 望月てる代, 上田愛子, 育代, 七枝美香, 小田光子, 岸田典子,日本栄養・食糧学会誌, 54, 291-295 (2001).

 

著書 その他

  1. 脂質・脂肪酸関連物質の使いこなし方, 有澤琴子, 市 育代, p69-74, 株式会社テクノシステム, 分担執筆 (2020)
  2. 食品と生体内に存在するオキシステロール, 市 育代, Heart View, 第22巻, 第7号, p60-64 (2018)
  3. 脂肪滴の大きさを調節する脂肪滴膜タンパク質と膜脂質 -脂肪滴の”表面”が脂肪滴のサイズを決める, 有澤琴子, 市 育代, 化学と生物, Vol. 56, No. 4 (2018)
  4. 新スタンダード栄養・食物シリーズ13臨床栄養学, 東京化学同人, 分担執筆(2017)
  5. 栄養科学シリーズNEXT 臨床栄養学実習第2版, 講談社, 分担執筆 (2017)
  6. 新スタンダード栄養・食物シリーズ9 基礎栄養学, 東京化学同人, 分担執筆 (2015)
  7. 栄養, 実教出版株式会社,分担執筆 (2015)
  8. 栄養科学イラストレイテッド 分子栄養学 遺伝子の基礎からわかる, 羊土社,  (2014)
  9. スマート栄養管理-栄養とスポーツの管理が重要であるこれだけの理由, 医歯薬出版, 分担執筆 (2014)
  10. 基礎生化学-健康・疾病とのつながり, アイ・ケイコーポレーション, 分担執筆 (2013)
  11. ビタミンの新栄養学, 講談社, 分担執筆 (2012)
  12. 食物と栄養学基礎シリーズ7 基礎栄養学, 学文社, 分担執筆 (2012)
  13. Antioxidants as biomarkers of oxidative stress. I. Ichi and S. Kojo, In Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications (Ed., G. Aldini, K.-J. Yeum, E. Niki, and R. M. Russell) pp. 35-49, Wiley-Blackwell, Iowa, USA (2010).

 

外部資金

  • 公益財団法人ニッポンハム食の未来財団2021年度研究助成(研究代表者)

研究課題:高度不飽和脂肪酸欠乏による食物アレルギー応答の制御機構

  • 科学研究費補助金・基盤研究(C) (令和2〜4年度)(研究代表者)

研究題目:多価不飽和脂肪酸欠乏による腸管-肝臓の臓器連関の破綻と分子機構の解明

  • 公益財団法人三島海雲記念財団平成30年度学術研究奨励金【自然科学部門】(研究代表者)

研究題目:必須脂肪酸欠乏時に産生される脂肪酸の疾患への関与とその制御機構の解明

  • 平成29年度公益財団法人食生活研究会助成金(研究代表者)

研究題目:必須脂肪酸欠乏におけるアレルギーの病態制御に関する研究

  • 科学研究費補助金・基盤研究(C) (平成29〜31年度)(研究代表者)

研究題目:必須脂肪酸欠乏の脂肪酸代謝の制御機構とその生理的意義の解明

  • 委託研究 バイエル薬品株式会社(平成27年度)

研究題目:プラーク浸食によって誘導される自発的なアテローム血栓症のモデルを用いたコレステロール合成阻害及びコレステロール吸収阻害の異なる影響に関する分析

  • 科学研究費補助金・若手研究(B) (平成27〜28年度)(研究代表者)

研究題目:栄養状態で変化する生体膜脂肪酸の生理学的意義

  • 厚生労働科研委託費(平成26年度)(研究分担者)

研究題目:LDLアフェレーシス療法施行中の重症家族性高コレステロール血症に対する、同種脂肪組織由来多系統前駆細胞(ADMPC)を用いた細胞移植法の確立

  • 第24回コスメトロジー研究助成(平成25年度)((研究代表者)

研究題目:必須脂肪酸欠乏時における皮膚障害発症のメカニズムの解明

  • 科学研究費補助金・基盤研究(C) (平成23〜25年度)((研究代表者)

研究題目:必須脂肪酸欠乏で増加するミード酸およびその代謝物の機能解析

  • 科学研究費補助金・若手研究(B) (平成20〜22年度)(研究代表者)

研究題目:動脈硬化における新規原因物質の解明と食品による抑制効果の探索

  • 平成19年度(財)森永奉仕会研究奨励金

研究題目:小児におけるセラミド動態の変化

 

 

 

 

 

 

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